Vitis Vinifera Seed Oil

Vitis Vinifera (Grape) Seed Oil is a non-volatile emollient lipid typically used at meaningful levels (often several percent up to higher in oil phases) to reduce transepidermal water loss and improve barrier feel, and it is generally well-tolerated in clinical use. Irritation and sensitization rates for the oil itself are low, but in very reactive/eczema-prone patients it can still provoke stinging or dermatitis (including from residual impurities/oxidation products), so it is best considered very gentle rather than universally inert. Safety Notes: In commercial skincare, Vitis Vinifera (Grape) Seed Oil is frequently used at trace levels (~0.01–0.1%) as part of a botanical oil blend or to support claim positioning in lotions/serums and some rinse-off cleansers. Mid-range use (1–20%) is common in leave-on creams, facial oils, and balm-type formulas where it functions as an emollient and carrier oil. The upper end reaches 100% in consumer-available single-ingredient grape seed oil products sold as face/body/hair oils, which are OTC and not restricted by cosmetic regulations beyond general safety/labeling requirements.