Vitis Vinifera Fruit Extract

Vitis vinifera (grape) fruit extract is primarily an antioxidant/polyphenol botanical used at low concentrations, but botanical extracts carry a meaningful risk of irritation due to variable phenolic content and trace impurities. In patch testing and real-world sensitive-skin use, reactions are uncommon but do occur (stinging, erythema, dermatitis), especially in eczema-prone users and when layered with other actives. Given the variability between suppliers and the heightened risk in compromised barriers, it fits a mild irritancy profile. Safety Notes: In mass-market leave-on skincare and rinse-off cleansers, Vitis Vinifera (Grape) Fruit Extract is frequently used as a label-claim antioxidant/soothing botanical at trace to low levels (often ~0.0001–0.1%), especially when supplied in dilute glycerin/propylene glycol/water carriers. More concentrated consumer serums, masks, and “polyphenol/resveratrol/grape antioxidant” products can push total grape fruit extract into the low single digits, with upper-end OTC products typically topping out around ~3–5% due to color/odor, phenolic astringency, and stability constraints; there is no specific EU/FDA maximum for this botanical extract, so practical formulation limits drive the observed cap.