Sodium Rna

Sodium RNA (a nucleic-acid–derived skin-conditioning/humectant ingredient) is typically used at low concentrations and is not a keratolytic or pH-dependent active, so it generally has low inherent irritation potential. However, as a biologically derived macromolecule, it can still provoke stinging or rare hypersensitivity in highly reactive or barrier-compromised eczema skin, especially when layered with other actives. Given patient-safety considerations and limited robust irritancy datasets compared with core humectants, I score it as very gentle rather than exceptionally gentle. Safety Notes: In commercial skincare, Sodium RNA (often positioned as a “DNA/RNA” moisturizing/skin-conditioning active) is most commonly used at very low levels in leave-on serums/creams, with trace-to-low additions around 0.0001–0.01% reflecting typical supplier-recommended use levels and cost/stability constraints. Mid-range products (anti-aging lotions, eye creams, sheet masks) frequently sit around ~0.01–0.1%. The highest OTC consumer-available claims observed reach about 0.5–1.0% in specialized “nucleic acid” ampoules/serums, with >1% being uncommon due to solubility, tackiness/feel, and preservation/bioburden considerations rather than a specific regulatory cap.