Sodium Dextran Sulfate

Sodium dextran sulfate is a highly water-soluble sulfated polysaccharide primarily used as a film-former/viscosity modifier or bioactive polymer; while often used at low levels, its strong anionic (sulfated) charge can increase stinging/irritation on compromised barriers compared with neutral dextrans. Clinically, sulfated polyanions are generally not common allergens, but they can be mildly irritating in eczema or post-procedure skin, so I score it as mild rather than gentle to reflect real-world reactive-patient risk and cumulative routine exposure. Safety Notes: In commercial skincare, sodium dextran sulfate is most often used at very low levels (~0.01–0.2%) in leave-on calming/anti-redness serums, post-procedure-style barrier products, and eye-area formulas where it functions as a soothing/anti-inflammatory polymer. Higher-strength consumer-available leave-on products (targeting visible redness, irritation, or blemish-associated inflammation) have been observed around ~0.5–2.0%; above this it becomes uncommon due to viscosity/feel, potential tackiness/film formation, and rising irritation risk. Rinse-off use is less common; when used, it typically stays toward the lower end because wash-off contact time limits benefit and higher levels can negatively impact texture and foaming.