Sh-Polypeptide-11

Sh-Polypeptide-11 is a synthetic/human-identical signaling peptide used in very low concentrations in leave-on products, and peptides as a class are generally well-tolerated with low rates of irritation in patch testing compared with acids, retinoids, or fragrance. The main safety concern is rare individual hypersensitivity to the peptide itself or residual impurities from manufacturing rather than intrinsic irritancy, so for highly reactive/eczema-prone skin it remains “very gentle” rather than inert. Safety Notes: Sh-Polypeptide-11 is a supplier-derived cosmetic peptide that is typically supplied as a diluted solution (often within a broader peptide/ferment blend) and is therefore used at very low active levels in commercial leave-on serums, eye products, and anti-aging creams, commonly landing in the ~0.00005–0.001% active range. Higher-strength consumer-available “peptide booster”/ampoule-style leave-on products and concentrated anti-wrinkle serums can push to about 0.01% active, above which cost, stability, and diminishing returns typically limit real-world OTC use. It is rarely a meaningful active in rinse-off products due to short contact time, so the observed market range is primarily based on leave-on formulations.