Sh-Pentapeptide-1

Sh-Pentapeptide-1 is a synthetic peptide used in anti-aging formulations at very low concentrations (typically 0.0001-0.001%), with clinical studies showing excellent tolerability and minimal irritation potential even in sensitive skin populations. Peptides of this molecular weight generally demonstrate low penetration and interaction with skin receptors, resulting in a favorable safety profile. While extremely rare sensitization reactions have been documented in literature, the ingredient's track record supports classification as very gentle and appropriate for daily use in most sensitive skin conditions. Safety Notes: Sh-Pentapeptide-1 (synthetic human Pentapeptide-1) is a highly potent cell-communicating peptide used in anti-aging formulations, typically found in leave-on serums and creams. The lowest commercial concentrations appear around 0.0001% in basic anti-aging moisturizers where it's a supporting ingredient, while specialized high-performance peptide serums can reach up to 0.01% as the active concentration. This peptide is extremely bioactive and expensive, so even at these seemingly low percentages, it represents significant formulation investment and efficacy at the cellular level.