Sh-Oligopeptide-2

Sh-Oligopeptide-2 is a signal peptide used in very low concentrations in leave-on products (typically trace to <0.1%) to support skin conditioning/anti-aging claims. As a non-exfoliating, non-solvent, non-surfactant peptide, it has a low inherent irritation profile and is generally well-tolerated in patch testing and clinical use, though any bioengineered peptide can rarely trigger stinging or sensitization in highly reactive eczema-prone patients. Given the low use level but non-zero risk in compromised skin, it best fits a very gentle score rather than inert. Safety Notes: In commercial skincare, Sh-Oligopeptide-2 (a recombinant/“sh-” signaling peptide) is typically dosed at very low levels because it is supplied as a dilute solution/blend and is used for marketing/biological signaling rather than as a bulk active; many mass-market leave-on serums and creams effectively land around 0.00001–0.0001% active. Higher-strength consumer anti-aging serums and ampoules commonly reach ~0.001% active, with a practical observed ceiling around 0.01% in OTC leave-on products due to cost, stability, and diminishing returns; it is rarely used in rinse-off formats where contact time is short.