Sh-Oligopeptide-1

Sh-Oligopeptide-1 (often used to denote recombinant human EGF in a sh-oligopeptide naming system) is a skin-conditioning peptide typically used at very low concentrations and is not inherently acidic or surfactant-like, so primary irritancy is generally low in most users. However, as a bioactive signaling peptide delivered in leave-on products, there is a non-zero risk of stinging or reactivity in compromised barriers (eczema/post-procedure), and published irritation data are less robust than for inert humectants, warranting a cautious but still gentle score. Safety Notes: Sh-Oligopeptide-1 (commonly used as EGF) is typically supplied as a very dilute solution and is therefore used in commercial leave-on serums/creams at extremely low finished-product levels (often around 0.000001–0.0001%) to achieve ppb–ppm active dosing while maintaining stability and cost targets. High-strength consumer-available EGF serums marketed as “high concentration” commonly land in the ~0.001% range, with the upper end around ~0.01% in niche OTC products (above which cost and stability/handling constraints become significant); rinse-off use is uncommon and generally at the very low end due to limited contact time.