Rice Sh-Oligopeptide-1

Rice Sh-Oligopeptide-1 is a recombinant/derived bioactive peptide used at very low concentrations as a skin-conditioning and signaling ingredient, and peptides are generally well-tolerated compared with acids, retinoids, or surfactants. However, as a protein/peptide-based material it carries a small but real risk of irritant or allergy-type reactions in highly reactive or eczema-prone patients (including potential impurities from the production system), so it cannot be scored as exceptionally gentle/inert. In routine leave-on use the overall irritation risk is low but not zero, warranting a gentle score. Safety Notes: Rice Sh-Oligopeptide-1 is a recombinant EGF-type peptide ingredient typically supplied as a highly diluted active (often further diluted into a finished formula), so commercial leave-on products commonly land in the low ppm to sub-ppm range (e.g., ~0.00001–0.0005%) when used primarily for marketing/skin-conditioning. Higher-strength OTC serums/ampoules marketed as “EGF” products can reach roughly ~0.001–0.01% active peptide in finished leave-on formulations, which aligns with upper-end market offerings and practical stability/cost constraints; rinse-off use is uncommon and generally at the very low end due to short contact time.