Polyglyceryl-6 Laurate

Polyglyceryl-6 Laurate is a nonionic surfactant/emulsifier used at low concentrations (typically ~0.5–5%) to solubilize oils and improve cleanser or lotion mildness, and it is generally well tolerated in patch testing compared with harsher anionic surfactants. However, as a laurate-based surfactant it can still disrupt barrier lipids in very compromised skin (eczema, post-procedure) and may sting on inflamed areas, especially when combined with other cleansing agents. For patient safety in severe sensitivities, I score it as gentle but not inert. Safety Notes: Polyglyceryl-6 Laurate is used as a nonionic, PEG-free emulsifier/solubilizer and mild surfactant; in leave-on emulsions/serums it is often present at low levels (~0.05–1%) as a co-emulsifier or solubilizer for oils/fragrance, while rinse-off cleansers and micellar-type systems more commonly use ~0.5–5% for detergency/solubilization. In consumer-available high-strength anhydrous cleansing balms, makeup removers, and self-emulsifying oil cleansers, it is observed at much higher levels (commonly 5–12% and up to ~15%) to ensure rapid rinse-off emulsification and stability; higher levels are constrained mainly by sensory (drag/soaping), potential eye sting, and formula viscosity rather than specific regulatory maximums.