Polyglyceryl-10 Dioleate

Polyglyceryl-10 dioleate is a non-ionic emulsifier/surfactant used at low-to-moderate levels (commonly ~0.5–5%) to solubilize oils and stabilize emulsions, and it is generally well-tolerated in patch testing compared with harsher anionic surfactants. Irritation risk is not zero because surfactants can disrupt the stratum corneum—especially in compromised barrier states (eczema, post-procedure) or in leave-on products layered with other actives—but clinically it is typically considered very gentle when properly formulated. Given its primary role and usual concentrations, a low but non-inert score best reflects patient-safety reality for highly sensitive skin. Safety Notes: Polyglyceryl-10 dioleate is used as a non-ionic lipophilic emulsifier/co-emulsifier and solubilizer in oil-rich systems; in commercial leave-on lotions/creams, cleansing oils, and makeup removers it is often present at low levels (~0.1–1%) as a stabilizer and sensory modifier alongside other emulsifiers. In higher-oil anhydrous cleansers, cleansing balms/oils, and self-emulsifying oil-to-milk products, it can be pushed into the high single digits and up to ~15% in consumer products to drive emulsification and rinse-off transform performance; higher levels are mainly seen in rinse-off/cleansing formats rather than typical leave-on moisturizers.