Physalis Angulata Extract

Physalis angulata extract is a botanical anti-inflammatory/soothing ingredient typically used at low concentrations, but as a plant extract it contains multiple bioactive compounds with batch-to-batch variability. Human irritation data are limited compared with standardized actives, and plant extracts can trigger irritant or allergic contact dermatitis in eczema-prone patients, especially in leave-on routines and on compromised skin. Given the uncertainty and sensitization potential despite generally gentle positioning, a mild-risk score is the safest clinically. Safety Notes: In commercial skincare, Physalis angulata extract is most often used as a botanical soothing/anti-inflammatory active at very low levels (often as part of a multi-botanical blend), with effective inclusion commonly starting around 0.001–0.01% in leave-on creams/serums and higher in rinse-off products where cost and odor/color control drive lower use. High-strength OTC positioning (e.g., “concentrated” soothing serums/ampoules or products built around a single featured botanical) can reach ~1–3% active extract depending on the supplier’s solvent system and solids content, with higher practical limits typically set by stability, sensory impact, and potential for botanical-related irritation rather than specific regulatory caps.