Palmitoyl Dipeptide-5 Diaminohydroxybutyrate

Palmitoyl Dipeptide-5 Diaminohydroxybutyrate is a lipidated signal-peptide used in anti-aging products at low concentrations (typically well under 1%), and peptides in this class are generally well-tolerated in standard patch-testing with low irritancy rates. While true allergy is uncommon, the palmitoyl (fatty) moiety and formulation context can occasionally contribute to stinging or mild reactions in highly reactive/eczema-prone skin, so it is not scored as inert. Overall, its intrinsic irritation potential is very gentle when used at typical cosmetic concentrations. Safety Notes: In commercial anti-aging/firming leave-on products, this peptide is most often delivered as part of a diluted supplier blend, with effective in-formula actives commonly falling in the low-ppm range; the lowest market-observed use is around 0.0001% active where it appears low on the INCI list as a supporting peptide. High-strength consumer serums and eye creams that position this as a key peptide typically top out around ~0.05% active due to cost and diminishing returns/stability considerations; rinse-off usage is uncommon and generally at the low end given limited contact time.