Oligopeptide-2

Oligopeptide-2 is a signaling peptide used in anti-aging/repair formulas at very low concentrations (typically well under 0.1–1%), and peptides in general show low rates of irritation in standard patch testing when properly formulated. The main real-world risk comes from the overall formula (preservatives, solvents, pH) rather than the peptide itself, but in highly reactive or eczema-prone skin any bioactive can sting on compromised barrier—so it is best classified as very gentle rather than inert. Safety Notes: In commercial skincare, Oligopeptide-2 is typically dosed at very low levels because it is supplied as dilute solutions and is used as an “active-support” peptide in leave-on serums/eye creams, with many products landing around 0.0001–0.01% active. The lowest observed levels (~0.00005%) occur in multi-peptide/complex formulas where it is included for claims support, while the highest OTC levels (~0.05%) are seen in specialized peptide serums/ampoules marketed as high-strength and formulated at the upper end of supplier use-guidelines for stability and cost. It is rarely used meaningfully in rinse-off products due to short contact time, so the practical market range is largely driven by leave-on applications.