Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1

This is a plant-produced recombinant EGF-like signaling peptide used at very low concentrations (typically ppm-level) for skin-repair/anti-aging claims, and such peptides are generally well tolerated with low direct irritancy in patch-test experience. However, as a bioactive growth-factor–type protein, it can occasionally provoke stinging or reactivity in highly compromised eczema skin, and the plant-expression context raises a small but non-zero risk of trace impurities triggering sensitivity. Given patient-safety prioritization for severely reactive populations, I rate it as gentle but not inert. Safety Notes: In commercial leave-on skincare, this plant-produced recombinant peptide blend (often supplied as a dilute solution and used as an “active” complex) is typically dosed at very low levels, with entry-level anti-aging serums/creams using around 0.00005–0.001% active to support marketing claims while maintaining stability and cost targets. Higher-strength consumer serums marketed as growth-factor/EGF-like or “bioactive peptide” formulas have been observed using up to ~0.05% active, which represents the upper end seen OTC before viscosity, stability, and cost become limiting. It is rarely used in rinse-off products, and when present there, levels generally sit at the low end due to short contact time.