Myristoyl Hexapeptide-16

Myristoyl Hexapeptide-16 is a lipidated signaling peptide used in anti-aging/firming products at low concentrations (typically well under 1%), and peptides as a class are generally well-tolerated in patch testing with low irritancy. The attached myristoyl (fatty) chain can very occasionally contribute to stinging or follicular intolerance in highly reactive or acne-prone users, but true irritation is uncommon at cosmetic use levels, supporting a very gentle score. Safety Notes: In commercial leave-on skincare (serums, eye creams, anti-aging moisturizers), Myristoyl Hexapeptide-16 is typically used at very low levels as a signal/lipofilic peptide, with many multi-peptide formulas dosing it around 0.0005–0.005% to manage cost and solubility while still supporting marketing/claims. Higher-strength consumer-available “peptide concentrate” serums and ampoules occasionally push toward ~0.02–0.05% as a standalone or lead peptide, which is near the upper practical end before stability/solubilization challenges and diminishing returns become limiting. It is overwhelmingly a leave-on ingredient; rinse-off uses are uncommon and, when present, tend to sit at the low end due to limited contact time.