Larrea Tridentata Extract

Larrea tridentata (creosote bush) extract is a botanical antioxidant/anti-inflammatory used at low percentages, but it contains resinous phenolics (e.g., NDGA-related constituents) that can be irritating and have a meaningful rate of reactivity in sensitized or eczematous skin. As with many plant extracts, variability in composition and co-extracted compounds increases the likelihood of stinging, redness, or dermatitis when used in leave-on products, especially in compromised barriers. Given the higher-risk sensitive-skin population and limited robust safety data compared with inert excipients, it warrants cautious introduction and a notable irritancy score. Safety Notes: Larrea tridentata (creosote bush) extract is most often used as a minor botanical antioxidant/soothing component in leave-on serums, moisturizers, and after-sun products at trace-to-low levels (typically ~0.01–0.5%), consistent with supplier use-level guidance for complex plant extracts. High-strength consumer products (botanical spot treatments, “concentrated” desert-plant serums, and some natural deodorant/antimicrobial-style balms) can push the extract to a few percent; the upper end (~5%) reflects the highest OTC levels observed where the extract is a primary featured active, with sensitization/odor/color and stability constraints usually limiting use above this in mainstream formulations.