Isopropyl Myristate

Isopropyl myristate is a common emollient/texture enhancer typically used at a few percent up to higher levels in creams and makeup; it is generally low-sting and not a classic primary irritant in standard patch testing. However, in eczema-prone or highly reactive skin it can contribute to barrier occlusion and follicular irritation (comedogenic/acne mechanica patterns) and may exacerbate dermatitis in some users when layered with other occlusives. Given this nontrivial but not universal risk profile in sensitive populations, it warrants a mild irritancy score. Safety Notes: In commercial products, Isopropyl Myristate is often used at very low levels (~0.1–1%) as a slip/skin-feel modifier or fragrance solubilizing/emollient aid in lotions, sunscreens, and some rinse-off cleansers. Typical leave-on emulsions commonly fall around 1–10%, while higher-strength consumer-available products such as anhydrous body oils, massage oils, makeup remover oils/balms, and some specialized barrier/balm formats can use it as a primary emollient at ~20–50%. Higher levels are limited mainly by desired sensory profile (greasiness/fast spread), comedogenicity concerns for facial use, and compatibility with certain polymers/packaging rather than hard regulatory caps.

Suitability