Hydroxyphenyl Propamidobenzoic Acid

Hydroxyphenyl Propamidobenzoic Acid (often marketed as SymSitive 1609) is a soothing/anti-itch ingredient typically used around ~0.1–0.5% to help reduce stinging and neurogenic redness in sensitive skin. Available safety and patch-test experience generally show low irritation and low sensitization potential at these concentrations, including in reactive-skin formulations. While not completely inert and rare individual reactions can occur, its clinical role and typical use levels support a very gentle score. Safety Notes: Hydroxyphenyl Propamidobenzoic Acid (commonly marketed as SymSitive 1609) is used in consumer soothing/anti-redness products at low levels around 0.05–0.10% to support sensitive-skin claims while minimizing cost and sensory impact. Many mainstream leave-on creams/serums cluster around ~0.10–0.30%, while high-strength OTC calming concentrates and barrier-repair serums marketed for reactive skin are observed up to about 1.0% in leave-on formats. It is less commonly used in rinse-off products, where levels tend to sit toward the low end due to short contact time.