Hydrolyzed Glycosaminoglycans

Hydrolyzed glycosaminoglycans are humectant/skin-conditioning polysaccharide fragments (often hyaluronic-acid–like materials) typically used at low concentrations (~0.1–1%) to support hydration and barrier feel, and they are generally well tolerated in patch-testing and clinical use. True irritation is uncommon but can occur in highly reactive or eczema-prone skin due to formulation factors (preservatives/impurities, high tack/occlusion, or compromised barrier), so it is not fully inert. Given its broad safety profile but nonzero risk in sensitized populations, it fits best as very gentle rather than completely irritation-free. Safety Notes: In commercial skincare, hydrolyzed glycosaminoglycans are typically used as a specialty humectant/skin-conditioning active at very low levels, with many leave-on moisturizers/serums and eye products listing it in the <0.1% range (often ~0.001–0.05%) to support hydration/feel without impacting viscosity or tack. Higher-strength consumer-available leave-on “hydration/plumping” concentrates and ampoules can reach ~0.5–2% (generally as the supplier’s active content rather than a dilute blend), while rinse-off cleansers tend to sit at the low end due to short contact time and cost. There is no specific FDA/EU maximum for this INCI, so the practical upper bound is driven by solubility, sensorial limits, and formula stability rather than regulation.