Hexapeptide-47

Hexapeptide-47 is a synthetic signaling peptide used in very low concentrations (typically well under 1%) to support barrier/anti-aging or calming claims, and peptides as a class show low irritancy in repeat-insult patch testing and clinical use. While true irritation is uncommon, any bioactive peptide can rarely trigger stinging or dermatitis in highly reactive or eczematous skin, so I do not score it as inert. At typical use levels and neutral formula pH, it is generally very gentle with a low but non-zero risk for compromised skin. Safety Notes: In commercial leave-on products (serums/creams/eye products), Hexapeptide-47 is most often used at very low levels typical of specialty peptides, with some formulas listing it at trace “label-claim” amounts around 0.0001–0.001% when supplied as a diluted peptide-in-solvent blend. Higher-strength consumer products that position peptides as a primary active generally top out around ~0.01–0.05% active Hexapeptide-47 due to cost, solubility, and stability constraints (peptides are commonly used well below 0.1% active in OTC skincare). Rinse-off usage is uncommon and, when present, tends to sit at the low end because of limited contact time.