Hexapeptide-11

Hexapeptide-11 is a synthetic signal peptide used in anti-aging products at very low concentrations (typically well below 0.1–1%), and peptides as a class have a low rate of irritant reactions in clinical and consumer patch testing. It is not pH-dependent and is generally non-stinging and compatible with compromised skin when properly formulated, though rare irritation can occur due to individual reactivity or formulation context (e.g., solvent/preservatives), so it is not scored as completely inert. Safety Notes: In commercial INCI lists, Hexapeptide-11 is most often used in leave-on anti-aging serums/creams at very low levels (commonly around 0.0005–0.01%), frequently as part of a peptide blend, with the lowest observed use around 0.0001% when included mainly for marketing or as a minor component of a complex. The highest OTC consumer-available claims and supplier-use practices for neat peptide actives put Hexapeptide-11 up to ~0.05% in high-strength leave-on peptide serums and concentrated ampoules; above this is uncommon due to cost and formulation/stability constraints. Rinse-off usage is rarer and typically stays at the low end because short contact time limits benefit.