Glucosylrutin

Glucosylrutin is a water-soluble flavonoid (rutin derivative) used mainly as an antioxidant/anti-inflammatory and anti-redness support ingredient, typically at low concentrations (~0.1–1%). Available human tolerance/patch-test experience with rutin derivatives suggests a low irritation profile, with adverse reactions being uncommon and usually limited to rare individual hypersensitivity rather than predictable irritancy. Given use in sensitive-skin formulas but acknowledging the non-zero potential for idiosyncratic reactions in compromised barriers, a very gentle score is most consistent with patient-safety expectations. Safety Notes: In commercial skincare, glucosylrutin (a more water-soluble rutin derivative used for antioxidant/anti-redness and capillary-support claims) is commonly present at low “supporting active” levels around 0.01–0.1% in leave-on serums/creams and around ~0.01–0.05% in rinse-off cleansers where contact time is short. Higher-strength consumer-available leave-on products (especially anti-redness, brightening, or antioxidant concentrates) are typically formulated in the ~0.5–1% range, with the upper end observed around ~2% in specialty high-active serums where solubility and color/odor constraints still allow use; no specific EU/FDA maximum is set for this ingredient, so practical formulation limits drive the top end.