Garcinia Mangostana Peel Extract

Garcinia mangostana (mangosteen) peel extract is used mainly as an antioxidant/anti-inflammatory botanical, typically at low concentrations, but it contains polyphenols/xanthones that can act as contact irritants or sensitizers in reactive or eczema-prone skin. Human irritation data are limited compared with standard emollients, so I score it as mild risk: generally tolerated, yet capable of stinging, redness, or delayed dermatitis in compromised barriers or when layered with other actives. Safety Notes: In mass-market leave-on skincare (serums, lotions, toners) mangosteen peel extract is commonly used as a supporting antioxidant/soothing botanical at very low levels (often ~0.001–0.1%), especially when supplied as a dilute liquid in glycerin/propylene glycol. Higher-strength consumer products marketed around ‘mangosteen’ (concentrated serums, ampoules, masks) can reach ~1–5% active extract, with ~5% representing the upper end typically seen OTC due to color/odor, polyphenol-driven stability/compatibility constraints, and cost. Rinse-off products generally sit toward the lower end of the range because brief contact time reduces the need for higher loading.