Disodium Rutinyl Disulfate

Disodium Rutinyl Disulfate is a water-soluble rutin (flavonoid) derivative used primarily as an antioxidant/anti-inflammatory skin-conditioning agent, typically at low concentrations (about 0.1–1%). Human irritation data are limited, but flavonoid antioxidants are generally well tolerated; however, the disulfate/salt modification can increase reactivity in very compromised skin, so I score it as gentle rather than very gentle to reflect a small but real irritation risk in highly sensitive or eczematous patients. Safety Notes: Disodium Rutinyl Disulfate is a water-soluble rutin derivative used mainly as an antioxidant/brightening and anti-redness active; in mass-market toners/serums it is often present at very low “supporting active” levels around 0.001–0.05%. In consumer-available targeted leave-on treatments (spot serums/ampoules) it is commonly formulated around ~0.1–1.0%, with a small number of high-strength OTC products/formulator disclosures reaching about 2% as an upper practical limit due to cost, solubility/ionic strength, and potential for increased tack/salt effects. It is rarely used meaningfully in rinse-off products (typically ≤0.05%) because contact time limits benefit, so the upper end of the range is primarily seen in leave-on formulations.