Diosmine

Diosmine is a flavonoid used primarily for vascular support/anti-inflammatory claims and, in topical products, is typically included at low levels; it is not a classic irritant active like acids or retinoids. However, human irritation data for leave-on facial use is limited, and plant-derived polyphenols can occasionally trigger stinging or dermatitis in highly reactive or eczematous skin, especially when paired with other actives. Given the uncertainty and the need to protect compromised skin populations, I score it as mild with a realistic risk of sensitivity in reactive individuals. Safety Notes: In consumer topical skincare, diosmin (diosmine) is most often used at low levels as a vasoactive/flavonoid support ingredient in eye/face leave-on products and anti-redness/anti-dark-circle formulas, commonly appearing around 0.01–0.1% when used as part of a botanical/flavonoid complex. Higher-strength OTC “capillary/venotonic” cosmetic gels and leg/under-eye treatments marketed for puffiness, bruising appearance, or visible veins can reach ~0.5–2% diosmin, typically in leave-on gels/creams where solubilization and grit/stability constraints limit practical upper loading; rinse-off use is uncommon and generally lower due to short contact time.