Capryloyl Glycine

Capryloyl glycine is a lipoamino acid used mainly for antimicrobial/sebum-regulating and deodorant effects, typically at low concentrations (~0.1–1%) in leave-on products. It is generally well-tolerated but is not fully inert; as a bioactive antimicrobial/acidic component it can sting or provoke mild irritant reactions in compromised barriers (e.g., eczema, post-procedure) and may add cumulative irritation when paired with acids/retinoids. Given sensitive-skin risk and the need to err on safety, it fits a mild irritancy profile rather than "gentle" or "very gentle." Safety Notes: In consumer skincare, capryloyl glycine is most often used as a sebum-regulating/anti-imperfection auxiliary and microbiome/deodorizing support ingredient at low levels (~0.05–0.3%) in moisturizers, serums, and gentle cleansers. Mid-range use (~0.3–1.0%) appears in anti-blemish leave-on products and oily-scalp/hair-care where it supports antimicrobial balance and feel. The highest OTC levels observed are around 1.0–2.0% in specialized acne/oil-control leave-on formulations (and some deodorant-style skincare), with higher levels limited by solubility/processing and potential for increased sensory tack or irritation depending on pH and system.