Calycophyllum Spruceanum Bark Extract

Calycophyllum spruceanum (capirona) bark extract is a botanical antioxidant/soothing-type extract typically used at low percentages, but published human irritation/sensitization data are limited compared with well-characterized dermatologic actives. Because bark extracts can contain variable polyphenols/alkaloid-like constituents and are more prone to batch-to-batch variability, they can trigger stinging or dermatitis in highly reactive or eczematous skin despite being marketed as “gentle.” Given the uncertainty and the higher-risk population (compromised barrier), a mild irritancy score is most consistent with cautious patient safety. Safety Notes: Calycophyllum spruceanum bark extract (commonly marketed as “Dragon’s Blood”/Sangre de Grado–type antioxidant/soothing extract) is most often used at very low levels in multi-ingredient serums/creams where the INCI is supported by a diluted commercial extract, with finished-product use levels commonly down around 0.0005–0.05% for leave-on products. Higher-strength OTC “Dragon’s Blood” booster serums and targeted calming/anti-redness concentrates have been observed using roughly 0.5–3% finished-product addition to achieve a strong marketing/claims position, with rinse-off formats typically clustering toward the lower end due to short contact time and cost.