Calcium Pantothenate

Calcium pantothenate (a stable salt form of vitamin B5) is primarily used as a skin-conditioning/humectant support ingredient, typically at low concentrations, and has a strong track record of good tolerability in patch testing and clinical use. True irritation or allergy is uncommon, but in highly reactive or eczematous skin any leave-on ingredient can occasionally sting on compromised barrier, so it is not fully inert. Considering its generally low reactivity yet non-zero potential on broken skin, it fits a very gentle (0.2) score. Safety Notes: In commercial skincare, calcium pantothenate (a salt form of vitamin B5) is most often used at very low levels as a supportive skin-conditioning/claim ingredient in multi-component creams, lotions, toners, and cleansers, with observed inclusions down around 0.0005–0.01% in broad-ingredient-list formulas. Leave-on products commonly sit in the ~0.05–0.5% band, while higher-strength OTC “B5/panthenate” serums, barrier creams, and scalp/anti-hair-fall type leave-ons can reach about 1–2% before solubility/salt load and sensory constraints typically limit further increases; rinse-off formats are usually at the low end due to short contact time. No specific EU/FDA cosmetic maximum applies, so the upper end is driven mainly by stability/solubility and product aesthetics rather than regulation.