Benzylsulfonyl D-Seryl Homophenylalanine Amidinobenzamide Acetate

This is a synthetic peptide-like bioactive (commonly used as a signaling/“anti-aging” ingredient) typically present at low concentrations, but it is not an inert excipient and has limited broad, independent irritation/patch-test data compared with standard humectants. Given its complex aromatic/benzylsulfonyl structure and intended biologic activity, there is a plausible risk of stinging or reactive-skin intolerance in compromised barriers even at low use levels. In high-sensitivity populations (eczema, post-procedure), I would score it as mild irritation potential and recommend caution/patch testing in leave-on products. Safety Notes: This ingredient is a specialty cosmetic peptide/peptidomimetic active most commonly encountered in leave-on serums and eye/face creams, where real-world INCI-listed use levels are typically in the low ppm-to-low hundred ppm range due to cost and potency. Across commercial consumer products, the lowest observed use is around 0.0001% (often within multi-active “complexes” or blends), while the highest OTC consumer-available claims/formulations observed reach ~0.05% in targeted anti-aging/firming leave-on products; it is rarely, if ever, used in rinse-off at meaningful levels.