Amyl Cinnamal

Amyl Cinnamal is a fragrance allergen (cinnamal derivative) used at very low concentrations for scent, but it is a well-documented cause of allergic contact dermatitis in patch testing, especially in eczema-prone or barrier-impaired patients. Even when compliant with typical leave-on limits, real-world cumulative exposure from multiple fragranced products increases risk, and reactions can be delayed and severe in sensitized individuals. Given its primary role as fragrance (non-essential) and meaningful sensitization potential, it warrants a significant irritancy score for sensitive-skin safety. Safety Notes: Amyl Cinnamal is used in skincare primarily as a fragrance allergen component within parfum compositions, so at the low end it appears in leave-on products (e.g., face creams/serums) at trace levels around 0.1–1 ppm (0.00001–0.0001%) when present only as an impurity/constituent of a fragrance blend. In real-world OTC fragranced body lotions, body creams, deodorants, and rinse-off washes, observed levels commonly sit in the ~0.001–0.05% range, while higher-fragrance formats (fine-fragrance-adjacent body products and some strongly perfumed washes) can reach about 0.1–0.2% without being prescription/professional. Note that regulatory requirements in the EU focus on allergen labeling thresholds (0.001% leave-on; 0.01% rinse-off) rather than hard maximum limits, which is consistent with the higher end being driven by fragrance load and IFRA-style risk management.