Ammonium Glycyrrhizate

Ammonium glycyrrhizate is a licorice-derived anti-inflammatory/soothing agent typically used at low concentrations (about 0.1–1%) to reduce redness and discomfort, and it is generally well tolerated in sensitive-skin formulas. Clinical and post-market experience suggest a low rate of irritation, but as a botanical-derived salt it can still trigger occasional reactivity in highly sensitized or eczema-prone individuals, so it cannot be considered inert. Safety Notes: In commercial skincare, ammonium glycyrrhizate is commonly used as a soothing/anti-redness agent at low levels around 0.01–0.1% in leave-on toners, emulsions, and sensitive-skin moisturizers (often as a supporting anti-irritant alongside panthenol/allantoin). Higher-strength consumer products—typically targeted brightening/spot serums, post-procedure calming gels, or concentrated ampoules—are observed up to ~1–2% where solubility, tack/feel, and potential irritation from highly active bases become practical formulation limits. Rinse-off cleansers and masks usually sit toward the lower end because contact time is short and high levels can impact foam and sensorial profile.