Agrimonia Eupatoria Leaf Extract

Agrimonia eupatoria (agrimony) leaf extract is a botanical astringent/soothing ingredient typically used at low concentrations (often <1–2%), but like many plant extracts it contains polyphenols/tannins that can sting or provoke irritant or allergic contact dermatitis in reactive or eczema-prone skin. Human patch-test and clinical safety data are limited and product-to-product variability is high, so I do not treat it as inherently “gentle.” Given the sensitization uncertainty and the risk of cumulative irritation in compromised barriers, a mild (0.4) score best matches patient-safety expectations. Safety Notes: In mass-market toners, cleansers, and creams, Agrimonia eupatoria (agrimony) leaf extract is most often used as a minor botanical supporting ingredient, commonly appearing at trace-to-low levels around 0.001–0.1% depending on the supplier’s extract strength and whether it’s part of a blended botanical complex. Higher-strength consumer-available “herbal/soothing” serums, masks, and ampoule-style products can push single botanical extracts into the low single digits, with observed use up to ~5% in leave-on formats when stability, odor/color, and skin tolerance permit. There are no specific FDA/EU maximum limits for agrimony extract itself, so the practical upper end is set by formulation aesthetics, preservative system compatibility, and irritation risk rather than regulation.