Acetyl Hexapeptide-37

Acetyl Hexapeptide-37 is a small signaling peptide used in anti-aging/hydration products, typically at very low concentrations (often well under 1%), and it is not pH-dependent or inherently exfoliating. Available cosmetic safety/usage data and clinical experience suggest peptides like this are generally well-tolerated with low rates of stinging or dermatitis, though rare reactions can occur in highly reactive or eczema-prone skin due to individual sensitization or formulation context. Given the low intrinsic irritancy but nonzero real-world risk in compromised barriers, it fits best as "very gentle" rather than completely inert. Safety Notes: In consumer leave-on serums/creams, Acetyl Hexapeptide-37 is most often used at very low levels because it is typically supplied as a diluted solution and is effective in the ppm-to-low-bps range; commercial products commonly land around ~0.001–0.01% active. The lowest observed levels in multi-peptide or “supporting peptide” formulas can be ~0.0001% active, while high-strength OTC peptide serums and booster-style products occasionally reach ~0.05% active (generally limited by cost, solubility in the chosen base, and preservation/stability considerations). Rinse-off use is uncommon and, when present, tends to sit toward the low end due to short contact time.