Acetyl Hexapeptide-1

Acetyl Hexapeptide-1 is a small signaling peptide used in low concentrations (typically well under 1%) for anti-aging/skin-conditioning, and it is generally non-stinging and non-exfoliating at functional use levels. Clinical and post-market data suggest a low incidence of irritation or sensitization compared with acids, retinoids, fragrances, and many preservatives, though rare reactivity can occur from the peptide itself or formula context. For highly reactive or eczema-prone skin, it remains a very gentle ingredient overall but not truly inert, supporting a 0.2 score. Safety Notes: In commercial leave-on skincare, Acetyl Hexapeptide-1 is often used at very low levels because it is typically supplied as a dilute solution and dosed to deliver trace-active peptide levels; products listing it near the end of the INCI commonly fall around ~0.0001–0.005% active. Higher-strength consumer anti-aging serums/ampoules and targeted eye/face treatments (still OTC) can reach ~0.01–0.05% active when formulators intentionally dose a concentrated peptide raw material. Rinse-off products rarely justify higher levels due to short contact time, so the upper end is predominantly observed in leave-on formulas.